Metabolic Phenotype Predicts Biochemical Response to Inositol Supplementation in Polycystic Ovary Syndrome: A Systematic Review and Meta‐Analysis

Key Points

• This research aims to assess how metabolic phenotype affects the biochemical response to inositol supplementation in women with PCOS.
• Conducted a systematic review and meta-analysis
• Analyzed biochemical responses to inositol across different metabolic phenotypes
• Examined outcomes such as hirsutism and ovulatory function
• Inositol supplementation significantly improved biochemical hyperandrogenism
• Normal-weight women with PCOS showed the most consistent responses
• Findings indicate a need for phenotype-specific trials focusing on meaningful clinical outcomes

Abstract