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April 14, 2026Frontiers in MedicineOpen Access

An exploratory randomized controlled trial protocol evaluating Cognitive Behavioral Therapy for Insomnia with adjunct Ayurvedic external therapies (Siro-pichu and Padabhyanga) in perimenopausal women

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Authors

PUP. UnnikrishnanDSDevipriya SomanSVSreedevi V

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Overview

Exploratory trial examines the effects of CBT and Ayurvedic therapies on insomnia in perimenopausal women, highlighting treatment feasibility.

Key Points

  • This study aims to explore the feasibility and preliminary effectiveness of combining CBT for insomnia with Ayurvedic therapies in perimenopausal women.
  • Conducted as a single-center, parallel-group, exploratory randomized controlled trial.
  • Included sixty-two perimenopausal women aged 45-55 with subthreshold to moderate insomnia.
  • Participants received standardized CBT-I for 4 weeks; the integrative arm received additional Ayurvedic therapies.
  • Siro-pichu was administered for seven days, and Padabhyanga for fourteen days, starting at baseline.
  • Change in insomnia severity index (ISI) score will be assessed at Week 4 as the primary outcome.
  • Secondary outcomes will evaluate early response at Week 2 and changes in sleep quality over 3 months of follow-up.
  • Exploratory measures include safety, treatment adherence, and behavioral dependency risk.

Cite This Study

Unnikrishnan et al. (2026) studied this question.

synapsesocial.com/papers/69ddd8eee195c95cdefd663ehttps://doi.org/10.3389/fmed.2026.1785264
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