PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
April 16, 2026Advanced NanoBiomed Research0 citationsOpen Access

Enhancing DNA Transfection Using Receptor-Mediated Endocytosis via TFAMoplex

Comparison of Receptor‐Mediated Endocytosis and Its Application to Enhance DNA Transfection by TFAMoplex

View Full Paper
Ask AI
Bookmark
Share

Authors

DSDavid SchererSHSteffen HonrathJKJonas Kurmann

Discussion

Loading...

Member takes

Overview

Flow cytometric assay identifies ligands to enhance gene delivery systems, indicating improved transfection efficacy.

Key Points

  • The aim is to improve gene delivery efficiency by identifying ligands that enhance receptor-mediated endocytosis.
  • Developed a flow cytometric assay to quantify internalized fluorescence for measuring endocytosis.
  • Identified effective ligands for enhancing cellular uptake in a high-throughput manner.
  • Applied identified ligands to TFAMoplex for improved nonviral gene delivery.
  • Effective ligands significantly increased TFAMoplex uptake.
  • Improved transfection efficacy was observed with identified ligands.
  • Assay provides a rapid screening method for uptake ligands.

Cite This Study

Scherer et al. (2026) studied this question.

synapsesocial.com/papers/69e07d1d2f7e8953b7cbe2dchttps://doi.org/10.1002/anbr.70124
View Full Paper
Ask AI
Bookmark
Share