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April 17, 2026Langmuir0 citations

Orientation-Dependent Adsorption and Thermodynamics of Human Serum Albumin at Polyurethane...

Orientation-Dependent Adsorption and Thermodynamics of Human Serum Albumin at Polyurethane Interfaces

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Authors

ASAmr H. SalehPMPatrice MalfreytMSMehdi Sahihi

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Overview

Molecular dynamics simulations uncover adsorption behavior of human serum albumin at polyurethane interfaces, indicating implications for material design.

Key Points

  • This research aims to investigate how the orientation of human serum albumin influences its adsorption at polyurethane interfaces.
  • Conducted all-atom molecular dynamics simulations to analyze protein adsorption.
  • Varying initial orientations of human serum albumin during simulations.
  • Utilized potential of mean force calculations to assess adsorption free energy profiles.
  • Adsorption behavior of human serum albumin is significantly influenced by its orientation.
  • Orientation-dependent adsorption reveals strong affinity states characterized by aromatic and hydrophobic residues.
  • Adsorption is thermodynamically favorable and primarily driven by enthalpic contributions.

Cite This Study

Saleh et al. (2026) studied this question.

synapsesocial.com/papers/69e1cf375cdc762e9d858196https://doi.org/10.1021/acs.langmuir.6c00072
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