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April 27, 2026Journal of Neurosurgery Pediatrics0 citations

Dual antiplatelet therapy in pediatric neurointerventional procedures: a retrospective case series

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JTJohn TumbergerChildren's Mercy HospitalATAlec ToewsThe University of Kansas Health SystemTLTravis R. LangnerUniversity of Kansas

Key Result

Dual antiplatelet therapy was well tolerated and appeared effective in preventing thromboembolic complications in pediatric patients after neurointerventional surgery.

Key Points

  • The study aims to assess the tolerability and effectiveness of dual antiplatelet therapy in pediatric neurointerventional procedures.
  • Retrospective case series analysis of pediatric patients undergoing neurointerventional surgery.
  • Evaluation of thromboembolic complications post-surgery while on dual antiplatelet therapy.
  • DAPT was well tolerated in pediatric patients.
  • DAPT appeared effective in preventing thromboembolic complications, warranting further investigation.

Structured PICO

Does dual antiplatelet therapy prevent thromboembolic complications in pediatric patients after neurointerventional surgery?

P
Population
pediatric patients after neurointerventional surgery
I
Intervention
Dual antiplatelet therapy (DAPT)
O
Outcome
thromboembolic complications and tolerabilitysafety

DAPT appears safe and effective for preventing thromboembolic complications in pediatric neurointerventional procedures, though prospective studies are needed to establish guidelines.

Limitations

  • retrospective design
  • lack of prospective studies to establish optimal dosing, timing, and duration

Abstract

In this case series, DAPT was well tolerated and appeared effective in preventing thromboembolic complications in pediatric patients after neurointerventional surgery. These findings support the use of DAPT in this population, although further prospective studies are needed to establish evidence-based guidelines for optimal dosing, timing, and duration of therapy.

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Cite This Study

Tumberger et al. (2026) studied this question. Dual antiplatelet therapy was well tolerated and appeared effective in preventing thromboembolic complications in pediatric patients after neurointerventional surgery.

synapsesocial.com/papers/69eefcaefede9185760d3a4bhttps://doi.org/10.3171/2025.12.peds25558
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