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April 28, 2026SHILAP Revista de lepidopterologíaOpen Access

Enhancement of chemotherapeutic efficacy via non-canonical autophagy induced by Olea europaea in human model of lung adenocarcinoma cells (A549)

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Authors

MRMaria del Pilar RomanoRPRosita Di PalmaMRMatteo Ruzza

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Overview

Randomized trial demonstrates improved anti-cancer effects in lung adenocarcinoma via olive extract, suggesting a novel therapeutic strategy.

Key Points

  • The aim is to evaluate the effects of Olea europaea extract in enhancing the efficacy of chemotherapeutic agents against lung adenocarcinoma cells.
  • Investigated the effects of olive fruit extract combined with 5-FU or CIS on A549 lung cancer cells.
  • Analyses included cell viability, autophagy markers, gene expression, ROS levels, and Nrf2 nuclear translocation.
  • Co-treatment with OE and chemotherapeutics significantly reduced cell viability and induced non-canonical autophagy.
  • Increased LC3BII and decreased Beclin-1 expression indicated autophagy without activating classical apoptotic markers.
  • Nrf2 nuclear translocation confirmed activation of the antioxidant response and modulation of ER stress.

Cite This Study

Romano et al. (2026) studied this question.

synapsesocial.com/papers/69f04d9f727298f751e71e62https://doi.org/10.3389/fcell.2026.1760977
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