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May 3, 2026

Progressive correction of auditory hair cell orientation in the absence of core planar cell polarity and GPR156 signaling.

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Authors

AJAmandine JarystaJNJustin NemelkaMRMuthumeena Ramanathan

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Overview

Randomized trial investigates the role of GPR156 in auditory hair cell orientation, revealing plasticity in defect correction.

Key Points

  • The central aim is to understand how auditory hair cells correct orientation defects without core planar cell polarity signaling.
  • Used viable conditional mutants lacking Vangl1/Vangl2 or Frizzled3/Frizzled6.
  • Examined postnatal reorientation of misoriented auditory hair cells.
  • Analyzed the role of GPR156 in the recovery of orientation defects.
  • Misoriented hair cells showed substantial correction over time postnatally.
  • GPR156 is essential for orientation but inhibits correction in core PCP mutant contexts.
  • Inhibition of GPR156 signaling facilitated correction in Vangl and Frizzled mutants.

Cite This Study

Jarysta et al. (2026) studied this question.

synapsesocial.com/papers/69f6e67c8071d4f1bdfc71fbhttps://doi.org/10.1242/dev.205332
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