Why the study?
Ischemic stroke heavily affects women, yet reliable biomarkers predicting risk remain limited, hindering early detection and prevention.
Are specific plasma proteomic profiles and pathways associated with incident ischemic stroke risk in women?
Population
450 incident IS cases and 450 matched controls among women in the Nurses' Health Study
Comparison
Incident IS cases vs matched controls
Design
Nested case-control study
Follow-up
Median time-to-event of 5.5 yrs
Key result
Proteomic analysis of 5,440 proteins identified 14 proteins significantly associated with ischemic stroke risk in women (q<0.05), highlighting distinct metabolic and inflammatory pathways.
Authors
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Hypothesis-generating for proteomic IS biomarkers in women; leaves open clinical utility pending prospective validation.
Case-Control (n=900)
Are specific plasma proteomic profiles and pathways associated with incident ischemic stroke risk in women?
p-value: p=<0.05
Large-scale proteomic analysis identified 14 circulating proteins and distinct metabolic and inflammatory pathways associated with ischemic stroke risk in women.
Sanchez et al. (2026) conducted a case-control in Ischemic stroke (n=900). Proteomic profiling vs. Matched controls was evaluated on Incident ischemic stroke (p=<0.05). Proteomic analysis of 5,440 proteins identified 14 proteins significantly associated with ischemic stroke risk in women (q<0.05), highlighting distinct metabolic and inflammatory pathways.