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May 7, 2026Journal of Proteome Research

Serum Exosomal ADGRF5: A Potential Diagnostic Biomarker for Metastasis in Triple-Negative Breast Cancer

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Authors

MZMeimei ZhaoYJYongwei JiangXKXiaomu Kong

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Overview

Randomized trial identifies serum exosomal biomarkers for TNBC metastasis, suggesting ADGRF5's diagnostic potential.

Key Points

  • This study aims to identify serum exosomal markers that can serve as early diagnostic indicators for metastasis in triple-negative breast cancer.
  • Conducted high-throughput proteomics on serum exosomes from metastatic and nonmetastatic TNBC patients.
  • Performed two sequential 4D-label free proteomic analyses involving 6 metastatic TNBC, 6 nonmetastatic TNBC, and 6 healthy controls.
  • Utilized Gene Ontology and ROC analyses to evaluate proteins and validated candidates with ELISA.
  • ADGRF5 distinguished metastatic TNBC from nonmetastatic TNBC with an AUC of 0.94.
  • Distinct exosomal protein expression profiles were found in metastatic TNBC compared to nonmetastatic TNBC and healthy controls.
  • Identification of serum exosomal markers provides a pathway for future breast cancer biomarker research.

Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/69fc2c1f8b49bacb8b347cd9https://doi.org/10.1021/acs.jproteome.5c01011
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