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May 8, 2026ChemistrySelect

Zwitterion: Important Tool for the Regioselective Synthesis of Five‑Membered Heterocycles: Mechanistic and Synthetic Perspectives

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Authors

STShrishti TripathiRKRajnish KumarRYRanjeet Kumar Yadav

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Overview

Review highlights the synthesis and mechanisms of five-membered heterocycles using zwitterions, suggesting innovative pathways.

Key Points

  • This review aims to explore the role of zwitterions in the regioselective synthesis of five-membered heterocycles.
  • Discussed various zwitterion types and their influence on reactivity patterns.
  • Evaluated in situ generation methods like base-mediated deprotonation and cycloaddition reactions.
  • Highlighted the use of zwitterionic intermediates in synthesizing pyrazoles, oxadiazoles, and other heterocycles.
  • Zwitterion-based syntheses enhance regioselectivity and minimize byproducts.
  • Syntheses often proceed under mild, environmentally friendly conditions.
  • The review emphasizes the promise of zwitterions in advancing pharmaceutical and materials science applications.

Cite This Study

Tripathi et al. (2026) studied this question.

synapsesocial.com/papers/69fd7e00bfa21ec5bbf063c5https://doi.org/10.1002/slct.73381
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