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October 1, 2002Annals of the New York Academy of Sciences12 citations

Effects of Methyllycaconitine and Related Analogues on Bovine Adrenal α3β4* Nicotinic Acetylcholine Receptors

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DBDarrell L. BryantRFR. Benjamin FreeSTSara M. Thomasy

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Abstract

Adrenal secretion and binding studies were performed using ring E analogues of methyllycaconitine to assess structural determinants affecting activity on bovine adrenal alpha3beta4* nicotinic receptors. The most potent analogues are as potent as many inhibitors of adrenal secretion. Our data support the potential use of methyllycaconitine analogues to generate nicotinic receptor subtype-specific compounds.

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Bryant et al. (2002) studied this question.

synapsesocial.com/papers/6a0481c67f46ef82ba7e7a4fhttps://doi.org/10.1111/j.1749-6632.2002.tb04448.x
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