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September 1, 1988Infection and Immunity375 citationsOpen Access

Measurement of Pseudomonas aeruginosa phenazine pigments in sputum and assessment of their contribution to sputum sol toxicity for respiratory epithelium

RWRobert WilsonDSDavid A. SykesDWDavid Watson

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Abstract

The phenazine pigments pyocyanin and 1-hydroxyphenazine were resolved by high-pressure liquid chromatography from the sputum sol phase from 9 of 13 patients with cystic fibrosis or bronchiectasis colonized by Pseudomonas aeruginosa. The concentrations measured were each sufficient to inhibit ciliary beating in vitro and contributed a significant proportion of sol phase toxicity for respiratory epithelium.

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Wilson et al. (1988) studied this question.

synapsesocial.com/papers/6a0690af2edded7c7b840b36https://doi.org/10.1128/iai.56.9.2515-2517.1988
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