Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 25, 2025PLoS Computational BiologyOpen Access

Integrated pan-cancer analysis of RNA binding protein HuR investigates its biomarker potential in prognosis, immunotherapy, and drug sensitivity

View Full Paper
Ask AI
Bookmark
Share

Authors

JPJian PengJQJichuan QuanXWXiaoru Wang

Discussion

Loading...

Member takes

Overview

Integrated analysis shows HuR's potential as a biomarker for prognosis and drug sensitivity in cancer, suggesting its role in immunotherapy effectiveness.

Key Points

  • HuR expression correlates with poor prognosis across multiple cancers, indicating its potential as an oncogenic driver.
  • High diagnostic accuracy was observed with HuR via TMB/PD-L1 biomarkers, demonstrating over 85% effectiveness.
  • The analysis utilized public datasets to assess HuR’s role in immune microenvironments and drug sensitivity predictions.
  • Establishing HuR as a key biomarker may enhance personalized treatment strategies and understanding of tumor progression.

Cite This Study

Peng et al. (2025) studied this question.

synapsesocial.com/papers/68af5f0dad7bf08b1eae1b4chttps://doi.org/10.1371/journal.pcbi.1013374
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 5357: The tumor-intrinsic RNA binding protein HuR is essential for anti-tumor immunity in PDAC2024
  2. 2Abstract A027: HuR drives immune evasion, metastases and KRAS addiction in pancreatic ductal adenocarcinoma: implications for IO-based and KRAS inhibitor therapies2025
  3. 3The Role of Tumor-Intrinsic HuR in Modeling the Pancreatic Tumor Microenvironment: Molecular Mechanisms and Therapeutic Opportunities2025 · 3 citations
  4. 4Human antigen R: Exploring its inflammatory response impact and significance in cardiometabolic disorders2024 · 4 citations
  5. 5RNA-binding protein HuR reprograms immune T cells and promotes oral squamous cell carcinoma2024 · 4 citations