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August 26, 2025Frontiers in Medicine1 citationsOpen Access

Dynamic changes of pulmonary function and immune function in children with mycoplasma pneumonia of different severity and their predictive value for disease prognosis: a retrospective cohort study

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ZLZheng LiuWDWen DengWXWenlin Xu

Key Points

  • Children with mycoplasma pneumoniae pneumonia display significant impairments in both pulmonary and immune function, indicating potential for recovery assessment.
  • Pulmonary function and immune profiles were markedly altered compared to healthy controls, highlighting disease severity.
  • Retrospective cohort analysis of 225 pediatric patients examined lung function and immunological indices across varying severity levels.
  • Dynamic changes in pulmonary and immune function markers may guide personalized management strategies for mycoplasma pneumoniae pneumonia.

Abstract

Purpose To explore the dynamic changes in pulmonary and immune function among children with Mycoplasma pneumoniae pneumonia (MPP) and evaluate their value in disease severity stratification and prognosis prediction. Method A retrospective cohort of 225 pediatric patients with varying degrees of MPP severity and disease course was analyzed. Lung function and immunological indices were measured and compared across groups. Results Children with MPP exhibited significant impairments in pulmonary function and alterations in immune profiles compared to controls. These changes were associated with both disease severity and recovery status. Conclusion Pulmonary and immune function markers may serve as useful indicators for assessing severity and recovery in pediatric MPP. Their clinical application could improve individualized management strategies.

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Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68af620aad7bf08b1eae2f1chttps://doi.org/10.3389/fmed.2025.1624256
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