Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 22, 2024Cancer Research

Abstract 3313: Discovery of a potent, selective, and orally available small molecule for disruption of the SOS1-RAS interaction

View Full Paper
Ask AI
Bookmark
Share

Authors

DKDong Hyuk KiYHYu HanaDKDonggeon Kim

Discussion

Loading...

Member takes

Overview

Key Points

Key points are not available for this paper at this time.

Cite This Study

Ki et al. (2024) studied this question.

synapsesocial.com/papers/68e72cd4b6db6435876a638ehttps://doi.org/10.1158/1538-7445.am2024-3313
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 5947: Discovery of ACE-47228211, a highly potent and selective SOS1 inhibitor2024
  2. 2Abstract 6056: Identification of first-in-class, orally bioavailable SOS1 bifunctional degraders for the treatment of KRAS- and RTK-driven cancers2024
  3. 3Abstract LB031: Discovery and Characterization of HH100937, a potent and selective SOS1 inhibitor demonstrates synergistic efficacy in combination with KRAS/MAPK therapies2024 · 3 citations
  4. 4Abstract 2080: SOS1 inhibition is an effective therapeutic strategy in SOS1-mutant cancer2024
  5. 5Abstract 441: Breaking the KRAS inhibitor induced resistance-wall: Targeting KRAS-SOS1 to disarm hypoxic survival.2026