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December 8, 2025Blood

Residual mutations in epigenetic modifiers are associated with poor prognosis and high relapse rate in Acute Myeloid Leukemia

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ZGZheng Ge

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Overview

The analysis demonstrates a significant relapse rate and poor overall survival in AML patients with residual mutations, primarily involving dnmt3a.

Key Points

  • The study aims to explore the impact of residual mutations on prognosis and relapse in Acute Myeloid Leukemia patients.
  • Analyzed genetic mutations in 122 AML patients using next-generation sequencing.
  • Sequenced bone marrow samples at diagnosis and complete remission.
  • Investigated the association between residual mutations and clinical outcomes.
  • Patients with residual mutations had a higher relapse rate (45.5% vs. 17.9% for clear mutations, P=0.001).
  • Worse overall survival was observed for patients with residual mutations compared to those without.
  • Identified distinct patterns of clonal evolution from diagnosis to relapse in the patient cohort.

Cite This Study

Zheng Ge (2025) studied this question.

synapsesocial.com/papers/69362f6e4fa91c937236e0a8https://doi.org/10.1182/blood-2025-1740
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