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August 27, 2021New England Journal of Medicine4,811 citationsOpen Access

Empagliflozin in Heart Failure with a Preserved Ejection Fraction

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SAStefan D. AnkerJBJaved ButlerGFGerasimos Filippatos

Key Result

Empagliflozin reduced the combined risk of cardiovascular death or hospitalization for heart failure in patients with preserved ejection fraction, regardless of diabetes status.

Key Points

  • To evaluate the impact of empagliflozin on cardiovascular outcomes in heart failure with preserved ejection fraction.
  • Clinical trial design
  • Included patients with heart failure and preserved ejection fraction
  • Assessed combined risk of cardiovascular death and hospitalization for heart failure
  • Empagliflozin significantly reduced the risk of cardiovascular death or hospitalization for heart failure
  • Effects observed regardless of diabetes status

Structured PICO

Does empagliflozin reduce the combined risk of cardiovascular death or hospitalization for heart failure in patients with heart failure and a preserved ejection fraction?

P
Population
Patients with heart failure and a preserved ejection fraction, regardless of the presence or absence of diabetes
I
Intervention
Empagliflozin
O
Outcome
Combined risk of cardiovascular death or hospitalization for heart failurecomposite

Empagliflozin reduces the composite risk of cardiovascular death or heart failure hospitalization in patients with HFpEF, independent of diabetes status.

Abstract

Empagliflozin reduced the combined risk of cardiovascular death or hospitalization for heart failure in patients with heart failure and a preserved ejection fraction, regardless of the presence or absence of diabetes. (Funded by Boehringer Ingelheim and Eli Lilly; EMPEROR-Preserved ClinicalTrials.gov number, NCT03057951).

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Cite This Study

Anker et al. (2021) studied this question. Empagliflozin reduced the combined risk of cardiovascular death or hospitalization for heart failure in patients with preserved ejection fraction, regardless of diabetes status.

synapsesocial.com/papers/6965117d7269e604acbf68f5https://doi.org/10.1056/nejmoa2107038
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