We introduce the notion of structural asymmetry in expectation in finite systems. First, we formalize a structural law: costs are intrinsic and persistent, while gains require structured input, inducing a default asymmetry. Second, we establish a collapse theorem: if the expected net change Φ = EΔV(t) < 0, the system collapses with probability one and finite expected lifetime. This framework clarifies that local optimization or positive expected returns do not ensure survival. Viability is governed by structural drift.
Ho Minh (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: