Relatives carrying an Ryr2 mutation exhibit marked phenotypic diversity but generally experience a low rate of arrhythmic events during follow-up.
Relatives carrying an Ryr2 mutation show a marked phenotypic diversity. The vast majority do not have signs of supraventricular disease manifestations. Mutation location may be associated with severity of the phenotype. The arrhythmic event rate during follow-up was low.
Werf et al. (2012) studied this question.