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April 27, 2009CirculationOpen Access

Beta-blockers were associated with a lower event rate, but cardiac and fatal or near-fatal events were still not rare during long-term follow-up.

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Why the study?

Are beta-blockers associated with a lower rate of cardiac and fatal or near-fatal events in catecholaminergic polymorphic ventricular tachycardia probands and affected family members?

Population

Catecholaminergic polymorphic ventricular tachycardia probands and affected family members

Design

Cohort

Follow-up

long-term

Authors

MHMeiso HayashiIDIsabelle DenjoyFEFabrice Extramiana

Discussion

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Overview

Residual risk persists on beta-blockers in CPVT; leaves open need for adjunctive therapies in prospective trials.

Structured PICO

Are beta-blockers associated with a lower rate of cardiac and fatal or near-fatal events in catecholaminergic polymorphic ventricular tachycardia probands and affected family members?

P
Population
Catecholaminergic polymorphic ventricular tachycardia probands and affected family members
I
Intervention
Beta-blockers
O
Outcome
Cardiac and fatal or near-fatal eventshard clinical

Despite beta-blocker therapy lowering event rates, CPVT patients still experience significant rates of fatal or near-fatal cardiac events, highlighting the need for additional therapies.

Cite This Study

Hayashi et al. (2009) studied this question.

synapsesocial.com/papers/69d573c85883a1e80be3bc36https://doi.org/10.1161/circulationaha.108.829267
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