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April 12, 20260 citationsOpen Access

Review on Lipid Nanoparticles of Tazarotene for Treatment of Psoriasis

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1S1Faizan Qureshi, *2Mrs. Sarita Yeole, 3Dr. Preeti Kulkarni, 4Ms. Amrita Bhoyar, 5Ms. Shashikala Bulgunde, 6Mrs. Abhilasha Dubey, 7Mrs. Akshara Indulkar, 8Mrs. Disha Devkar, 9Mr. Prasad Shirole

Key Points

  • To examine the potential use of lipid nanoparticles for delivering tazarotene in psoriasis treatment.
  • Review of existing literature on lipid nanoparticles and tazarotene.
  • Analysis of psoriasis pathophysiology and treatment options.
  • Evaluation of the effectiveness of nanoparticle delivery systems.
  • Lipid nanoparticles can enhance the absorption and efficacy of tazarotene.
  • Improved targeting of skin lesions may be possible with lipid nanoparticles.
  • Lipid formulations could minimize side effects associated with tazarotene application.

Abstract

Psoriasis is a chronic autoimmune inflammatory skin disorder characterized by accelerated keratinocyte proliferation and dysregulated immune responses, leading to visible skin lesions such as erythematous plaques and scales. Normally, skin cells mature and shed over a month; however, in psoriasis this process occurs within 3–4 days, causing cellular accumulation on the skin surface. Globally, psoriasis affects approximately 2–3% of the population, with notable gender and age variations, including a higher prevalence among men in India. The disease presents in multiple forms, including plaque, inverse, guttate, pustular, and erythrodermic psoriasis, each differing in severity, distribution, and clinical features. Plaque psoriasis is the most common type, accounting for 80–90% of cases. Psoriasis is associated with significant complications such as psoriatic arthritis, cardiovascular disease, metabolic syndrome, psychological disorders, and increased cancer risk. Clinical manifestations commonly include thick scaly plaques,

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1Faizan Qureshi, *2Mrs. Sarita Yeole, 3Dr. Preeti Kulkarni, 4Ms. Amrita Bhoyar, 5Ms. Shashikala Bulgunde, 6Mrs. Abhilasha Dubey, 7Mrs. Akshara Indulkar, 8Mrs. Disha Devkar, 9Mr. Prasad Shirole (2026) studied this question.

synapsesocial.com/papers/69db38274fe01fead37c64e9https://doi.org/10.5281/zenodo.19495071
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