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April 16, 2026Alzheimer s & Dementia0 citationsOpen Access

Circadian rest/activity rhythms and change in MRI‐derived brain volumes: Differences by age in a cognitively healthy sample

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MKMarc A. Kaizi‐LutuDCDaniel D. CallowJRJill A. Rabinowitz

Key Points

  • The aim is to explore the relationship between circadian rest/activity rhythms and changes in brain volumes, focusing on age variations.
  • Analyzed MRI-derived brain volumes of participants
  • Focused on medial temporal lobe and global brain volumes
  • Considered age as a variable in data interpretation
  • Circadian rest/activity rhythms were associated with increased medial temporal lobe and global brain volumes.
  • The strength of these associations varied across different age groups.

Abstract

Results link RARs with medial temporal lobe and global brain volumes and indicate that these associations may differ by age. Research is needed on the effects of RAR-focused interventions on brain health.

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Cite This Study

Kaizi‐Lutu et al. (2026) studied this question.

synapsesocial.com/papers/69e07cc02f7e8953b7cbdef4https://doi.org/10.1002/alz.71190
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