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April 16, 20260 citationsOpen Access

Platelet Repair System Failure: The Core Argument on the Unified Etiology of Four Chronic Diseases

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FAFOO SENG ANG

Key Points

  • The aim is to propose a unified theory that explains the common root cause of four chronic diseases.
  • Review of existing literature on systemic lupus erythematosus, Alzheimer's disease, Parkinson's disease, and ALS.
  • Comparison of pathogenesis mechanisms of the diseases.
  • Development of a theoretical framework connecting the diseases to platelet repair failure.
  • Identified that systemic lupus erythematosus is characterized by systemic repair failure.
  • Established that Alzheimer's, Parkinson's, and ALS are linked to localized repair failures in specific brain regions.
  • Challenged existing theories surrounding immune system involvement in these diseases.

Abstract

This paper proposes a unified etiological theory for four chronic intractable diseases: Systemic Lupus Erythematosus (SLE), Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis (ALS). The core hypothesis is that all four diseases share the same root cause: the failure of the human body's platelet repair system. SLE is a systemic repair failure, while the other three are localized repair failures in different brain regions. This theory completely overturns the traditional "immune system self-attack" hypothesis, establishing a closed and unassailable logical framework for chronic disease pathogenesis.

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Cite This Study

FOO SENG ANG (2026) studied this question.

synapsesocial.com/papers/69e07d3c2f7e8953b7cbe3dehttps://doi.org/10.5281/zenodo.19571331
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