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May 2, 20260 citations

Normative Gray Matter Stiffness Gradients in the Human Brain Predict Patterns of Cortical Injury after Concussion.

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AHAdnan A HiradSMSteven P MeyersAVArun Venkataraman

Key Points

  • This research aims to explore how gray matter stiffness gradients relate to cortical injury following a concussion.
  • Analyzed gray matter microarchitecture using diffusion MRI and magnetic resonance elastography (MRE).
  • Evaluated gray matter disruption over the timeline of mild traumatic brain injury (mTBI).
  • Identified specific stiffness gradients that correlate with injury patterns after concussion.
  • Demonstrated the ability of MRE to detect disruptions in gray matter throughout the mTBI process.

Abstract

evidence that joint diffusion MRI and MRE analysis sharpens mechanistic interpretations of gray matter microarchitecture and detects gray matter disruption across the mTBI timeline.

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Cite This Study

Hirad et al. (2026) studied this question.

synapsesocial.com/papers/69f594fc71405d493afffdbfhttps://doi.org/10.1177/08977151261446503
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