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May 6, 2026Organic & Biomolecular Chemistry0 citations

Racemising 3-aryl-3-hydroxy-2-oxindoles in a Pickering emulsion under acid catalysis and its application to dynamic kinetic resolution

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JMJihoon MoonSAShuji AkaiKKKyohei Kanomata

Key Points

  • To explore a method for racemising 3-aryl-3-hydroxy-2-oxindoles using acid-catalysis in a Pickering emulsion.
  • Utilized a water-in-oil Pickering emulsion with toluene and aqueous H2SO4 for racemisation.
  • Applied acid-catalysis to facilitate the reaction under biphasic conditions.
  • Developed methodology aimed at overcoming decomposition issues during racemisation.
  • Successfully racemised 3-aryl-3-hydroxy-2-oxindoles under acid-catalysis.
  • The biphasic methodology showed enhanced stability compared to traditional methods.
  • Demonstrated effectiveness in dynamic kinetic resolution applications.

Abstract

3-Aryl-3-hydroxy-2-oxindoles were racemised under acid-catalysis in a water-in-oil Pickering emulsion comprising toluene and aqueous H 2 SO 4 . The developed biphasic methodology overcomes the decomposition issues often encountered during alcohol racemisation and affords...

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Cite This Study

Moon et al. (2025) studied this question.

synapsesocial.com/papers/69fa97ce04f884e66b5319fehttps://doi.org/10.1039/d6ob00544f
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