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May 6, 2026RSC Medicinal Chemistry0 citationsOpen Access

Light-Controlled Inhibition of Gram-Positive Bacteria by Photoswitchable Amphiphilic Lipids (PALs)

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GFGuilherme FernandesSKSeong Heun KimCHCharlotte K. Hind

Key Points

  • This research aims to explore the antibacterial potential of light-controlled amphiphilic lipids against gram-positive bacteria.
  • Development of photoswitchable amphiphilic lipids (PALs)
  • Testing of PALs against various strains of gram-positive bacteria
  • Assessment of the modulation of antibacterial potency through light exposure.
  • Successful light-controlled inhibition of gram-positive bacteria
  • Ability to reverse antibacterial potency through light modulation
  • Demonstration of enhanced efficacy compared to traditional amphiphilic lipids.

Abstract

Amphiphilic lipids are potent membrane-disrupting antibacterials, but their activity cannot normally be modulated after administration. Here we report photoswitchable amphiphilic lipids (PALs) that enable reversible, light-controlled modulation of antibacterial potency...

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Cite This Study

Fernandes et al. (2026) studied this question.

synapsesocial.com/papers/69fa97ce04f884e66b531abbhttps://doi.org/10.1039/d6md00096g
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