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May 6, 2026Chemical Research in Toxicology1 citations

The Expanding Landscape of ADP-Ribosylation: Protein, DNA, RNA, and Mitochondrial Regulation

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YSYi-Cheng SinLZLinlin Zhao

Key Points

  • This research aims to explore the roles of ADP-ribosylation in regulating DNA and post-translational modifications.
  • Analysis of ADP-ribosylation types in mammalian and bacterial cells
  • Discussion of terminal and nucleobase-linked ADP-ribosylation
  • Examination of NAD capping and its interactions
  • Identified multiple types of ADP-ribosylation in DNA and RNA
  • Explored the interplay between ADP-ribosylation and protein modifications
  • Discussed physiological implications of these modifications

Abstract

-dependent modifications of DNA and RNA in mammalian and bacterial cells, including terminal and nucleobase-linked ADP-ribosylation and NAD capping, and discuss outstanding questions regarding their physiological functions and interplay with protein post-translational modification and other nucleic acid modifications.

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Cite This Study

Sin et al. (2026) studied this question.

synapsesocial.com/papers/69faa22704f884e66b532ca0https://doi.org/10.1021/acs.chemrestox.6c00176
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