Splenic metastases are uncommon in solid malignancies, and isolated splenic metastases are even more rare. Current research believes that both anatomical and immunological factors contribute to the rarity of splenic metastasis. We reported a rare case of metachronous isolated splenic metastasis of sigmoid carcinoma in a 58-year-old male. The combination of splenectomy, chemotherapy, and targeted therapy plus anti-PD-1 antibody helped the patient achieve tumor-bearing survival for 32 months. This study reviewed cases of isolated splenic metastasis from colorectal cancer, emphasizing the importance of comprehensive treatment in the treatment of solitary splenic metastasis to reduce the risk of development of new metastasis.
Yan et al. (2026) studied this question.