Background: To critically evaluate the biological and epigenetic pathways through which pranayama may influence metabolic regulation relevant to the prevention and management of type 2 diabetes mellitus. This review also synthesizes mechanistic findings across oxidative stress pathways, mitochondrial bioenergetics, inflammatory signaling, cortisol dynamics, and autonomic regulation to analyze how breath-based interventions may modulate diabetes-related molecular and physiological processes. Methods: Databases were searched for the decade 2014–2024 using the Keywords “Pranayama,” or “Pranayama therapy,” and “Oxidative stress,” and “Mitochondrial function,” and “cortisol,” and “Autonomic nervous system,” in combination with “Type 2 Diabetes” or “Diabetes Mellitus.” The review aimed to provide a comprehensive discussion of the current topic and, thus, does not include any specific data synthesis. Results: Current literature demonstrates that pranayama modulates several biological pathways implicated in both the development and management of type 2 diabetes. Studies report reductions in reactive oxygen species (ROS) and improvements in total antioxidant capacity (TAC), indicating enhanced regulation of oxidative stress. Improved NAD + levels and COX-II activity suggest a positive influence on mitochondrial function. Additionally, pranayama has been shown to lower cortisol levels and C-reactive protein (CRP) while improving autonomic balance, all of which are associated with improved insulin sensitivity and glycemic control. Conclusions: By mitigating oxidative stress, enhancing mitochondrial efficiency, modulating inflammation, lowering stress-related cortisol secretion, and improving autonomic nervous system tone, pranayama may support both the prevention and management of type 2 diabetes. Future randomized controlled trials are warranted to further validate these mechanisms and clinical outcomes.
Shah et al. (2026) studied this question.