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May 7, 2026Pediatric Blood & Cancer0 citationsOpen Access

Ethnic Differences in the Association Between SOD2 rs4880 and Hepatotoxicity in Pediatric Acute Lymphoblastic Leukemia: A Report From the REDIAL Consortium

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EMEmily J. MasonJWJohn P. WoodhouseJYJoanna S. Yi

Key Points

  • To explore the relationship between SOD2 genetic variants and hepatotoxicity in pediatric leukemia across different ethnic groups.
  • Analyzed genetic data from children with Acute Lymphoblastic Leukemia
  • Compared hepatotoxicity rates between Hispanic and non-Hispanic children
  • Calculated adjusted odds ratios for hepatotoxicity linked to SOD2 rs4880 variant.
  • Hispanic children showed increased odds of hepatotoxicity (aOR = 1.81) associated with SOD2 rs4880 variant
  • Non-Hispanic children demonstrated decreased odds of hepatotoxicity (aOR = 0.55)
  • Evidence of genetic variations impacting hepatotoxic risk across ethnicities.

Abstract

), but decreased odds in non-Hispanic children (aOR = 0.55, 95% CI: 0.32-0.94, p = 0.03). These findings highlight potential ethnicity-specific differences in genetic contributors to TAH risk and highlight the need for mechanistic studies.

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Cite This Study

Mason et al. (2026) studied this question.

synapsesocial.com/papers/69fbe3aa164b5133a91a2dddhttps://doi.org/10.1002/1545-5017.70387
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