Is pre-β1-lipoprotein closely related to Lp(a) lipoprotein and associated with coronary heart disease?
Pre-β1-lipoprotein is closely related or identical to Lp(a) lipoprotein, suggesting its potential utility as a biomarker for identifying individuals at high risk for developing coronary heart disease.
Certain properties of the atypical serum lipoprotein, referred to as pre‐ β 1 ‐lipoprotein, suggested that it might be identical to the lipoprotein carrying the Lp(a) antigen: Lp(a) lipoprotein. Both lipoprotein phenomena are under genetic control and occur in a certain proportion of healthy people. Pre‐ β 1 ‐lipoprotein occurs more frequently in patients with coronary heart disease (CHD) than in the healthy population. The present study of Finnish CHD patients was undertaken to investigate whether a close relationship could be revealed between pre‐ β 1 ‐lipoprotein and Lp(a) lipoprotein, as well as between Lp(a) lipoprotein and CHD. Both expectations were realised, and we conclude that pre‐ β 1 ‐lipoprotein is very closely related, if not identical to Lp(a) lipoprotein. If the present results are confirmed in future studies, serum analysis for Lp(a) lipoprotein/pre‐ β 1 ‐lipoprotein may become a useful tool for the identification in early life of members of a subpopulation which is particularly at risk for developing CHD.
Berg et al. (1974) studied this question.