Why the study?
Does syndecan-4 mediate collagen cross-linking and myocardial stiffening in pressure-overloaded hearts?
Population
syndecan-4(-/-) mice and wild-type mice subjected to aortic banding (AB), and cardiac fibroblasts
Comparison
syndecan-4 knockout (syndecan-4) and in vitro… vs Wild-type mice or control fibroblasts
Design
Preclinical
Key result
Syndecan-4 promotes collagen cross-linking and myocardial stiffening in the pressure-overloaded heart via both its cytosolic domain (NFAT signaling) and extracellular domain.
Authors
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Should not yet change clinical practice in pressure overload; hypothesis-generating for dual-domain syndecan-4 targeting.
Does syndecan-4 mediate collagen cross-linking and myocardial stiffening in pressure-overloaded hearts?
Syndecan-4 plays a dual role in promoting collagen cross-linking and myocardial stiffening during pressure overload via NFAT signaling and extracellular domain interactions.
Herum et al. (2015) studied Diastolic dysfunction and pressure-overloaded heart. Aortic banding (AB) in syndecan-4(-/-) mice vs. Wild-type mice was evaluated on Passive tension of left ventricular muscle strips and collagen cross-linking. Syndecan-4 promotes collagen cross-linking and myocardial stiffening in the pressure-overloaded heart via both its cytosolic domain (NFAT signaling) and extracellular domain.