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August 15, 2025Open Access

A Novel Cell-Free DNA Fragmentomics Assay and Its Application for Monitoring Disease Progression in Real-Time for Stage IV Cancer Patients

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Authors

SSSudhir K. SinhaHBHiromi BrownKKKnopf Knopf

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Overview

Prospective study reveals a real-time PCR approach to monitor treatment efficacy in metastatic cancer, indicating quicker clinical decision-making.

Key Points

  • The progression score model achieved an area under the curve of 0.93 for predicting disease progression.
  • Patients with a progression score above 90 showed a 92% incidence of progression, while those below 10 showed 95% non-progression.
  • Real-time quantitative PCR was used to analyze size-distributed cell-free DNA fragments in cancer patients.
  • This non-invasive assay can improve outcomes and reduce costs by detecting ineffective treatments earlier.

Cite This Study

Sinha et al. (2025) studied this question.

synapsesocial.com/papers/689fc6912abb084d53ed27d6https://doi.org/10.20944/preprints202508.0913.v1
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