Figure S15 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer

Key Points

• mTOR inhibition initiates ferritinophagy and ferroptosis in head and neck cancer, enhancing treatment efficacy.
• Combination therapy with mTOR inhibitors and auranofin improves ferroptosis, potentially increasing cancer treatment success.
• Analysis included genome-wide CRISPR screening to explore mechanisms of mTORi in cancer models, showing significant findings.
• Research highlights the importance of targeting ferritinophagy in cancer therapy, indicating new pathways for treatment.