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August 15, 2025Open Access

Figure S5 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer

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Authors

KKKeiichi KoshizukaXWXingyu WuKSKuniaki Sato

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Overview

Genome-wide CRISPR screening reveals mTOR inhibition initiates ferritinophagy and ferroptosis in HNSCC cells, suggesting potential cancer treatment pathways.

Key Points

  • mTOR inhibition initiates ferritinophagy in HNSCC cells and patient samples, facilitating cell death.
  • Experiments demonstrate that inhibiting mTOR leads to observable effects on ferritinophagy and ferroptosis.
  • Analysis employs genome-wide CRISPR screening to uncover the mechanisms involved in cancer cell death under mTOR inhibition.
  • Findings highlight the potential of targeting mTOR for therapeutic strategies in managing head and neck cancer.

Cite This Study

Koshizuka et al. (2025) studied this question.

synapsesocial.com/papers/68af56faad7bf08b1eadd1edhttps://doi.org/10.1158/0008-5472.29919017
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