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September 10, 2025The Journal of Organic Chemistry0 citations

Palladium-Catalyzed Carbonylative Synthesis of Amide-Containing 3,4-Dihydroisoquinolin-1(2H)-ones from N-Propargylamides

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WCWei ChenSLShuwei LiXWXiaolong Wang

Key Points

  • The reaction yields high amounts of amide-containing 3,4-dihydroisoquinolin-1(2H)-one derivatives efficiently.
  • Using TFBen as a CO source enhances safety and convenience during the carbonylation process.
  • The cyclization method employs amines to incorporate the amide unit into the target scaffold.
  • These findings indicate potential for developing varied amide structures through this palladium-catalyzed approach.

Abstract

A palladium-catalyzed cyclization and carbonylation of N-propargylamides with amines has been developed, which incorporates an amide unit into 3,4-dihydroisoquinolin-1(2H)-one scaffolds. By using benzene-1,3,5-triyl triformate (TFBen) as the safe and convenient CO source, the reaction proceeded smoothly to afford a variety of amide-containing 3,4-dihydroisoquinolin-1(2H)-one derivatives in high yields.

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Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68c18f469b7b07f3a06161fehttps://doi.org/10.1021/acs.joc.5c01621
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