Retroperitoneal liposarcoma is a type of tumor originating from various non-specific organs in the retroperitoneum and is the most common retroperitoneal tumor. Due to its deep location and insidious onset, early clinical manifestations are not obvious, and it is generally discovered only when the tumor is large, causing complications by invading or pressing on nearby tissues and organs. This article reports a case of a patient with a giant retroperitoneal liposarcoma who underwent radical resection. Postoperative pathological examination confirmed it to be a dedifferentiated liposarcoma. This case details the surgical removal of a giant retroperitoneal dedifferentiated liposarcoma and the successful postoperative recovery of the patient, vividly illustrating the surgical skills and perioperative management strategies required to handle such challenging cases. This case provides valuable surgical experience for managing giant retroperitoneal liposarcoma and highlights the practical significance of a surgery-focused comprehensive treatment in improving the quality of life for patients.
Wang et al. (2025) studied this question.