Supplementary Figure 10 from SPP1+ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8+ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

Key Points

• Tumor-associated macrophages significantly contribute to immunotherapy resistance in clear-cell renal cell carcinoma.
• The study identifies CD8 T-cell dysfunction as a key mechanism via which macrophages exert their effects.
• CyTOF technology was used for the identification of macrophages in the tumor microenvironment.
• Understanding macrophage roles may lead to improved therapeutic strategies for cancer treatment.

Abstract