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September 10, 2024Journal of Medicinal Chemistry

Contilisant+Tubastatin A Hybrids: Polyfunctionalized Indole Derivatives as New HDAC Inhibitor-Based Multitarget Small Molecules with In Vitro and In Vivo Activity in Neurodegenerative Diseases

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Authors

MTMireia Toledano‐PinedoAPAlicia Porro-PérezLSLinda Schäker‐Hübner

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Cite This Study

Toledano‐Pinedo et al. (2024) studied this question.

synapsesocial.com/papers/68e58de3b6db6435875297bfhttps://doi.org/10.1021/acs.jmedchem.4c01367
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Design, Synthesis and Mechanistic Study of New Dual Targeting HDAC/Tubulin Inhibitors2024 · 5 citations
  2. 2Synthesis and Biological Evaluation of Novel 2-Aroyl Benzofuran-Based Hydroxamic Acids as Antimicrotubule Agents2024 · 3 citations
  3. 3Design, synthesis and antitumor activity evaluation of Benzimidazole derivatives with potent HDAC inhibitory activity2024
  4. 4Development of Indole-3-yl-methylene-thiobarbital Derivatives as Inhibitors of HDAC8 Enzyme Activity2026
  5. 5A new class of Indole-based HDAC8 inhibitors as potential anti-lung cancer agents: In silico design, synthesis, biological assessment and binding interaction analysis2026