Abstract B033: Characterizing the spatial transcriptomic landscape of Osteosarcoma from diagnosis to relapse

Abstract Introduction This study aims at elucidating mechanisms of immune infiltration in osteosarcoma (OSA) to identify novel therapeutic strategies. Methods Here, joint analysis of spatial transcriptomics (ST, Visium) data from 26 formalin-fixed paraffin embedded OSA samples at diagnosis (n=9) and relapse (n=17, MAPPYACTS NCT02613962 2024 Sep 5-8; Toronto, Ontario, Canada. Philadelphia (PA): AACR; Cancer Res 2024;84(17 Suppl):Abstract nr B033.