Mp67-16 Preoperative Estimation Model for Pathological T3 Upstaging in Patients With Clinical T1-2 Clear Cell Renal Cell Carcinoma Underwent Surgery: Analysis From the International Marker Consortium for Renal Cancer (Inmarc)

You have accessJournal of UrologyKidney Cancer: Localized: Surgical Therapy V (MP67)1 May 2024MP67-16 PREOPERATIVE ESTIMATION MODEL FOR PATHOLOGICAL T3 UPSTAGING IN PATIENTS WITH CLINICAL T1-2 CLEAR CELL RENAL CELL CARCINOMA UNDERWENT SURGERY: ANALYSIS FROM THE INTERNATIONAL MARKER CONSORTIUM FOR RENAL CANCER (INMARC) Akinori Nakayama, Wei Chen, Masaki Kobayashi, Shohei Fukuda, Hajime Tanaka, Margaret F. Meagher, Rachel Greenwald, Benjamin Schmeusser, Edouard A. Nicase, Ithaar H. Derweesh, Viraj A. Master, Yasuhisa Fujii, and Kazutaka Saito Akinori NakayamaAkinori Nakayama , Wei ChenWei Chen , Masaki KobayashiMasaki Kobayashi , Shohei FukudaShohei Fukuda , Hajime TanakaHajime Tanaka , Margaret F. MeagherMargaret F. Meagher , Rachel GreenwaldRachel Greenwald , Benjamin SchmeusserBenjamin Schmeusser , Edouard A. NicaseEdouard A. Nicase , Ithaar H. DerweeshIthaar H. Derweesh , Viraj A. MasterViraj A. Master , Yasuhisa FujiiYasuhisa Fujii , and Kazutaka SaitoKazutaka Saito View All Author Informationhttps://doi.org/10.1097/01.JU.0001009496.54470.10.16AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Recent studies have shown that pathological T3 (pT3) upstaging are associated with worse prognosis in clear cell renal cell carcinoma (ccRCC). Preoperative estimation for that could be important in clinical T1-2 (cT1-2) RCC. We identified the risk factors and created preoperative risk model for pT3 upstaging, using the International Marker Consortium for Renal Cancer (INMARC) dataset. METHODS: The subjects of this study were 1750 cT1-2N0M0 ccRCC patients underwent radical or partial nephrectomy between March 2000 and June 2022. Risk factors for pT3 upstaging were identified from preoperative available factors of age, sex, tumor diameter on preoperative images, preoperative CRP, albumin and corrected Ca. A risk model for pT3 upstaging was developed. RESULTS: The median patient age was 61 years (interquartile range IQR: 52–69). The number of females and males was 569 (32.5%) and 1180 (67.5%), respectively. Postoperative pT3 upstaging was found in 298 patients (17.0%). Multiple logistic regression analysis for pT3 upstaging demonstrated that age 65 years or older (p<0.001), tumor diameter 5 cm or more (p<0.001), CRP 10 mg/L or more (p<0.001) and albumin less than 3.5 g/dL (p<0.001) were independent risk factors. All of these factors were scored as 1 point. The risk classification was 0 points, 1-2 points, and 3-4 points for low-, intermediate-, and high-risk group, respectively. The pT3 upstaging rates in the low-, intermediate-, and high-risk groups were 4.6%, 20.0%, and 65.7%, respectively. CONCLUSIONS: We developed a preoperative estimate model for pT3 upstaging in cT1-2 ccRCC patients. This model contributes to the selection of patients underwent careful surgery. Download PPTDownload PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e1104 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Akinori Nakayama More articles by this author Wei Chen More articles by this author Masaki Kobayashi More articles by this author Shohei Fukuda More articles by this author Hajime Tanaka More articles by this author Margaret F. Meagher More articles by this author Rachel Greenwald More articles by this author Benjamin Schmeusser More articles by this author Edouard A. Nicase More articles by this author Ithaar H. Derweesh More articles by this author Viraj A. Master More articles by this author Yasuhisa Fujii More articles by this author Kazutaka Saito More articles by this author Expand All Advertisement PDF downloadLoading ...