Mp52-01 Psma-Pet for Initial Biochemical Recurrence After Radical Prostatectomy

You have accessJournal of UrologyProstate Cancer: Localized: Surgical Therapy II (MP52)1 May 2024MP52-01 PSMA-PET FOR INITIAL BIOCHEMICAL RECURRENCE AFTER RADICAL PROSTATECTOMY Umar Ghaffar, Vidit Sharma, Giuseppe Reitano, Spyridon P. Basourakos, Grant M. Henning, Mohamed E. Ahmed, Ekamjit S. Deol, Geoffrey B. Johnson, Jack Andrews, Eugene D. Kwon, and Robert J. Karnes Umar GhaffarUmar Ghaffar , Vidit SharmaVidit Sharma , Giuseppe ReitanoGiuseppe Reitano , Spyridon P. BasourakosSpyridon P. Basourakos , Grant M. HenningGrant M. Henning , Mohamed E. AhmedMohamed E. Ahmed , Ekamjit S. DeolEkamjit S. Deol , Geoffrey B. JohnsonGeoffrey B. Johnson , Jack AndrewsJack Andrews , Eugene D. KwonEugene D. Kwon , and Robert J. KarnesRobert J. Karnes View All Author Informationhttps://doi.org/10.1097/01.JU.0001008864.84854.b7.01AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: PSMA-PET-CT has emerged as a valuable modality for detecting biochemically recurrent (BCR) prostate cancer (PCa) and has outperformed conventional imaging (CI) especially in patients with high-risk disease. We performed a retrospective review to assess detection efficacy, patterns of recurrence and factors predicting positive PSMA-PET with initial BCR after radical prostatectomy (RP). METHODS: Retrospective review of PSMA-PET scans performed at our institution until 02/27/2023 was conducted to identify patients with initial BCR detected by PSMA-PET after RP. Primary outcome was detection rate and secondary outcomes included patterns of recurrence, comparison with CI and factors impacting detection via PSMA-PET. RESULTS: 153 patients were identified. Detection rate at BCR was 60.5% (92/153) for PSMA PET-CT. Patterns of lesion on PSMA-PET were local recurrence 21.6% (33/153), vesicourethral anastomosis 4.6% (7/153), regional node 31.4% (48/153), distant node 11.1% (17/153), osseous metastasis 10.5% (16/153), visceral metastasis 3.3% (5/153). PSMA scan was negative 26.1% (40/153) and indeterminate in 13.1% (20/153) cases. Among 115 patients who had CI within 3 months available, PSMA-PET had significantly higher lesion detection than CI (59.6% vs 45.6%; p=0.002). Post-PSMA PET management strategies included salvage radiation (65.3%), androgen deprivation therapy (60.1%), chemotherapy (2.6%) and metastasis directed therapy (5.3%). Pathologic N1 stage (OR 4.45; 95% CI 1.05-18.91; p=0.043) and positive surgical margins (2.58; 95% CI 1.05-6.31; p=0.038) were significant predictors of lesion detection on multivariable analysis. CONCLUSIONS: PSMA-PET has high detectability of lesion in BCR patients and may be utilized to guide management. Pathologic N1 stage and positive surgical margins are significant predictors of lesion detection. Source of Funding: N/A © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e851 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Umar Ghaffar More articles by this author Vidit Sharma More articles by this author Giuseppe Reitano More articles by this author Spyridon P. Basourakos More articles by this author Grant M. Henning More articles by this author Mohamed E. Ahmed More articles by this author Ekamjit S. Deol More articles by this author Geoffrey B. Johnson More articles by this author Jack Andrews More articles by this author Eugene D. Kwon More articles by this author Robert J. Karnes More articles by this author Expand All Advertisement PDF downloadLoading ...