What type of study is this?

This is a Human Clinical Trial study (also classified as: Phase 2).

December 6, 2025Open Access

Study protocol of a randomized controlled phase II trial comparing nivolumab, ipilimumab plus radiotherapy versus nivolumab plus ipilimumab for advanced or recurrent esophageal cancer: Japan Clinical Oncology Group study JCOG2311 (ART NOUVEAU)

Key Points

Radiotherapy combined with nivolumab and ipilimumab shows promise for advanced esophageal cancer treatment.
Primary endpoint focuses on assessing treatment efficacy in adult patients with recurrent esophageal cancer.
Randomized controlled trial protocol registered under Japan Clinical Oncology Group study JCOG2311.
Support for exploring innovative therapies may enable improved outcomes in esophageal cancer patients.

Abstract

This trial has been registered on November 5th, 2024, in the Japan Registry of Clinical Trials as jRCT1031240461 (https://jrct.mhlw.go.jp/en-latest-detail/jRCT1031240461).

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Discussion

Cite this study

Tsushima et al. (Tue,) studied this question.

www.synapsesocial.com/papers/69337cefb3f947a0a125a3f8 — DOI: https://doi.org/10.1186/s12885-025-15403-2

Also consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Japanese Classification of Esophageal Cancer, 12th Edition: Part II· 2024 · 71 citations
New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)· 2008 · 29,240 citations
Nomograms for Calculating the Number of Patients Needed for a Clinical Trial with Survival as an Endpoint· 1982 · 351 citations
Comprehensive registry of esophageal cancer in Japan, 2016· 2025 · 19 citations

Authors

Takahiro Tsushima

Kota Kawabata

Satoru Matsuda

Journals

BMC Cancer

Actions

Institutions

Keio University

Hamamatsu University School of Medicine

Shizuoka Cancer Center

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Study protocol of a randomized controlled phase II trial comparing nivolumab, ipilimumab plus radiotherapy versus nivolumab plus ipilimumab for advanced or recurrent esophageal cancer: Japan Clinical Oncology Group study JCOG2311 (ART NOUVEAU)

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Cite this study

Also consider

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion