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January 14, 2026PolymersOpen Access

pH-Responsive Polyethylene Oxide-Based Electrospun Nanofibers for Controlled Drug Release in Infected Wound Treatment

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Authors

QYQian-Yu YuanLYLan YangBSBing-Chiuan Shiu

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Overview

Composite fibers demonstrate controlled drug delivery in infected wounds, indicating potential for tissue repair.

Key Points

  • The study aims to develop a composite fiber membrane for controlled drug release in infected wounds.
  • Developed a fiber membrane using polyethylene oxide, chitosan, and ascorbic acid
  • Conducted in vitro drug release experiments to assess release rates
  • Investigated pH-sensitivity of the membrane under acidic conditions
  • Tested the membrane's antioxidant activity and antibacterial effectiveness against E. coli and S. aureus.
  • CS increases fiber diameter while Asc reduces it, affecting the membrane's microstructure
  • Drug release is faster in acidic conditions, similar to those found in infected wounds
  • The membrane retains antioxidant activity and inhibits growth of E. coli and S. aureus.

Cite This Study

Yuan et al. (2026) studied this question.

synapsesocial.com/papers/6966e6f513bf7a6f02bff021https://doi.org/10.3390/polym18020191
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