What question did this study set out to answer?

To analyze the microbiological profile and clinical outcomes of patients with hospital-acquired pneumonia in ICU.

January 14, 2026Open Forum Infectious Diseases0 citationsOpen Access

P-1066. Microbiological profile of nosocomial pneumonias in the icu of a third level public health center of the dominican republic

DLDavid De Luna YRYori A Roque SBScott Borgetti

Puntos clave

To analyze the microbiological profile and clinical outcomes of patients with hospital-acquired pneumonia in ICU.
Conducted a retrospective observational study
Analyzed patients diagnosed with hospital-acquired pneumonia and ventilator-associated pneumonia
Utilized blood and bronchial secretions for culture analysis
Statistical analysis performed using Chi-square test and ANOVA for cross-variable analysis
60 patients met inclusion criteria, with 70% male and average age of 44.5 years
60% had associated co-morbidity, primarily hypertension and diabetes
63.3% of cultures showed no growth; P. auriginosa was the most isolated microorganism
Septic shock increased likelihood of culture positivity, mainly for P. auriginosa and E. coli
No significant difference in survival related to culture results

Resumen

Abstract Background Hospital-acquired pneumonia (HAP) accounts for approximately 22% of all hospital-acquired infections, with an attributable mortality rate reaching up to 33% in critically ill patients. HAP increases length of stay, broad-spectrum antibiotic use, costs, and complications, negatively affecting patient outcomes Figure 1. Species of microorganism isolated in blood culture and culture of bronchial secretion Methods A retrospective cross-sectional observational study was conducted to analyze the microbiological profile and clinical outcomes of patients diagnosed with HAP/VAP during the period from July 1, 2023, to July 1, 2024.HAP and VAP were defined using IDSA guideline criteria, with HAP in those hospitalized 48 hours, and VAP 48 hours of mechanical ventilationPatients were required to have at least one culture report from blood or bronchial aspirate obtained via tracheal cannula (MiniBAL).Statistical analysis was performed using the Chi-square test (χ²)and ANOVA for variable cross-analysisFigure 2.Association between group age and bacterial isolation on bornchial culture Results Of a total of 270 records analyzed, only 60 patients met the inclusion criteria, of which 42 (70%) were male;The average age was 44.5 +/- 18.42 years, with the range of 18-29 being the most frequent (30%). 60% of the patients had an associated co-morbidity, HTN (30%) followed by DM (23.3%), were the most frequent.The average LOS was 22.5 (+/- 9.46) days, where 91.7% of patients were ventilatedRegarding cultures, 63.3% reported no growth, with P. auriginosa being the most frequent (15%), followed by E. coli (6.7%) and A. baumanii (5%). (Figure 1), we found a statistical relationship between the age groups and the isolated microorganism (p=0.025).During septic shock events, microorganisms were isolated more frequently, with P. auriginosa and E. Coli being the most frequent, in 7 and 3 cases, respectively, we did not find a difference between survival and cultures reported without growth (P value 0.334). (Figure 2) Conclusion In this study, lack of culture growth was not associated with better survivalCritical illness with Septic shock had higher likelihood of culture positivityThese findings reinforce the importance of monitoring specific complications according to age groups and the identified microorganism to improve clinical outcomes. Disclosures All Authors: No reported disclosures

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