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January 14, 2026eLifeOpen Access

Lipid balance and chemoresistance in cancer cells

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Authors

KKKaori KanemaruYNYusuke Nakamura

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Overview

Research reveals how cholesterol affects chemoresistance in cancer cells, suggesting lipid interplay could influence treatment outcomes.

Key Points

  • This research examines the relationship between lipid balance and chemoresistance in cancer cells.
  • Studied hybrid epithelial-mesenchymal cancer cells
  • Analyzed the effects of cholesterol and sphingomyelin on drug response
  • Evaluated chemotherapy drug sensitivity
  • A shift in lipid balance reduces responsiveness to specific chemotherapy drugs
  • Cholesterol elevation correlates with increased chemoresistance
  • Sphingomyelin levels impact treatment efficacy

Cite This Study

Kanemaru et al. (2026) studied this question.

synapsesocial.com/papers/6966f31513bf7a6f02c00adehttps://doi.org/10.7554/elife.110231
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chemotherapy resistance due to epithelial-to-mesenchymal transition is caused by abnormal lipid metabolic balance2026 · 1 citations
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  3. 3Lipid metabolism dynamics in cancer stem cells: potential targets for cancers2024 · 6 citations
  4. 4Lipid Droplets in Cancer: New Insights and Therapeutic Potential2026 · 6 citations
  5. 5Impact of Chemotherapy and Hormone Therapy on Lipid Metabolism in Breast Cancer Patients: A Case Report and Literature Review2024