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January 14, 2026DiagnosticsOpen Access

The Whole Transcriptome Sequencing Profile of Serum-Derived Exosomes and Potential Pathophysiology of Age-Related Hearing Loss

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Authors

GYGuijun YangZXZhongqin XieYHYu Huang

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Overview

Systematic analysis identifies key lncRNAs and biomarkers associated with age-related hearing loss, suggesting potential therapeutic targets.

Key Points

  • To analyze lncRNA expression profiles in serum-derived exosomes related to age-related hearing loss.
  • Collected peripheral blood samples from ARHL patients and controls.
  • Isolated serum exosomes using nanoparticle tracking analysis, electron microscopy, and Western blot.
  • Performed lncRNA transcriptome sequencing and functional analysis including GO and KEGG.
  • Identified 2874 differentially expressed lncRNAs, with 988 downregulated and 1886 upregulated.
  • Detected 2132 differentially expressed mRNAs, with 882 downregulated and 1250 upregulated.
  • Key biomarkers THAP2, ZNF225, MED12, and RNF141 were validated as candidates for ARHL.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/6966f32713bf7a6f02c00db4https://doi.org/10.3390/diagnostics16020248
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