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January 14, 2026Dentistry JournalOpen Access

The Evolution of Extended Platelet-Rich Fibrin Membranes for Socket Grafting: Part Two: A Randomized Clinical Trial Comparing These Membranes with Collagen Membranes

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Authors

NENathan E. EstrinPAParas AhmadTTTroy B. Tran

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Overview

Randomized clinical trial demonstrates equal dimensional maintenance in ridge preservation for e-PRF membranes versus collagen membranes, suggesting enhanced wound healing.

Key Points

  • This research aims to compare extended platelet-rich fibrin membranes with collagen membranes for socket grafting outcomes.
  • Conducted a single-center randomized clinical trial with 55 patients requiring tooth extraction and implant placement.
  • Grafted sockets with sticky bone and secured using either collagen or e-PRF membranes.
  • Evaluated ridge dimensions using cone beam computed tomography at baseline and 3 months post-op; measured soft tissue thickness at both intervals.
  • At 3 months, e-PRF membranes showed comparable improvements in ridge dimensions and soft tissue thickness to collagen membranes.
  • Early wound healing was significantly better in the e-PRF groups compared to collagen membranes (p = 0.029).
  • Bio-Filler groups had significantly reduced fabrication/application times compared to membrane groups.

Cite This Study

Estrin et al. (2026) studied this question.

synapsesocial.com/papers/6966f32713bf7a6f02c00df8https://doi.org/10.3390/dj14010045
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Evolution of Extended Platelet-Rich Fibrin Membranes for Socket Grafting: Part Two: A Randomized Clinical Trial Comparing These Membranes with Collagen Membranes.2026
  2. 2Comparing two types of platelet-rich fibrin membranes in the management of dehiscence defects with simultaneous implant placement in the posterior mandible: a randomized controlled trial2026 · 1 citations
  3. 3Extended platelet rich fibrin versus allograft as a space filling material in immediate dental implant placement2026
  4. 4Eggshell membrane as a regenerative material in alveolar bone grafting in combination with advanced platelet rich fibrin.2024 · 2 citations
  5. 5Comparative Evaluation of A-PRF+ or Collagen Membrane on Hard and Soft Tissue Changes Following Immediate Implant Placement: A Randomized Clinical Trial2026