New‐Onset Complex Partial Seizures Progressing to Intractable Epilepsy in a Young Female With Bifrontal Encephalomalacia and a Remote History of Traumatic Brain Injury

ABSTRACT Encephalomalacia, the irreversible loss of brain tissue following injury, is a well‐documented cause of post‐traumatic epilepsy, typically manifesting within the first year. However, delayed‐onset intractable epilepsy in young adults remains underrecognized. We present a case of a young female with bifrontal encephalomalacia secondary to a traumatic brain injury (TBI) six years prior who developed complex partial seizures progressing to intractable epilepsy. Electroencephalography (EEG) confirmed seizure activity predominantly from the right frontal lobe. Despite multiple anti‐seizure medications, the patient required intensive care management for refractory status epilepticus. This case highlights the potential for chronic epileptogenesis in TBI survivors, emphasizing the need for long‐term vigilance, strict medication adherence, and proactive follow‐up to optimize seizure control and prevent recurrence.