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January 14, 2026Open Forum Infectious DiseasesOpen Access

P-1069. Patterns and Prevalence of Carbapenemase-Producing Organisms Identified in Nebraska Healthcare Facilities Following Whole Genome Sequencing (2019-2024)

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Authors

KBKathryn C BurbachKSKyle StrandMAMuhammad Salman Ashraf

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Overview

Retrospective review identifies carbapenem-resistant pathogens in Nebraska, highlighting the role of WGS for accurate detection.

Key Points

  • To evaluate the effectiveness of Whole Genome Sequencing (WGS) in detecting and characterizing carbapenemase-producing organisms (CPOs) in Nebraska.
  • Retrospective review of clinical isolates submitted to the Nebraska Public Health Laboratory from 2019 to 2024.
  • Isolates tested included carbapenem-resistant Acinetobacter spp, Enterobacterales, and Pseudomonas.
  • Positive isolates underwent WGS and analysis using the CDC’s Phoenix pipeline.
  • A total of 170 isolates were reviewed, with 54.7% identified to harbor a carbapenemase gene.
  • E.coli and K.pneumoniae were the most prevalent CPOs.
  • WGS detected eight CPOs missed by Carba-R, primarily in Acinetobacter spp.

Cite This Study

Burbach et al. (2026) studied this question.

synapsesocial.com/papers/6966f33b13bf7a6f02c012c7https://doi.org/10.1093/ofid/ofaf695.1264
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